The role of the cerebellum in the pathophysiology of Parkinson's disease.
Identifieur interne : 000C39 ( Main/Exploration ); précédent : 000C38; suivant : 000C40The role of the cerebellum in the pathophysiology of Parkinson's disease.
Auteurs : Mechelle M. Lewis [États-Unis] ; Shawna Galley ; Samantha Johnson ; James Stevenson ; Xuemei Huang ; Martin J. MckeownSource :
- The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques [ 0317-1671 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- pathology : Parkinson Disease.
- physiopathology : Cerebellum, Neural Pathways.
- Disease Progression, Humans.
Abstract
Parkinson's disease (PD), the most common neurodegenerative movement disorder, has traditionally been considered a "classic" basal ganglia disease, as the most obvious pathology is seen in the dopaminergic cells in the substantia nigra pars compacta. Nevertheless recent discoveries in anatomical connections linking the basal ganglia and the cerebellum have led to a re-examination of the role of the cerebellum in the pathophysiology of PD. This review summarizes the role of the cerebellum in explaining many curious features of PD: the significant variation in disease progression between individuals; why severity of dopaminergic deficit correlates with many features of PD such as bradykinesia, but not tremor; and why PD subjects with a tremor-predominant presentation tend to have a more benign prognosis. It is clear that the cerebellum participates in compensatory mechanisms associated with the disease and must be considered an essential contributor to the overall pathophysiology of PD.
PubMed: 23603164
Affiliations:
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Le document en format XML
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Lewis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA, USA Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA, USA Department of Pharmacology, Pennsylvania State University-Milton S. 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Le journal canadien des sciences neurologiques</title><idno type="ISSN">0317-1671</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebellum (physiopathology)</term><term>Disease Progression</term><term>Humans</term><term>Neural Pathways (physiopathology)</term><term>Parkinson Disease (pathology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebellum</term><term>Neural Pathways</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Disease Progression</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD), the most common neurodegenerative movement disorder, has traditionally been considered a "classic" basal ganglia disease, as the most obvious pathology is seen in the dopaminergic cells in the substantia nigra pars compacta. Nevertheless recent discoveries in anatomical connections linking the basal ganglia and the cerebellum have led to a re-examination of the role of the cerebellum in the pathophysiology of PD. This review summarizes the role of the cerebellum in explaining many curious features of PD: the significant variation in disease progression between individuals; why severity of dopaminergic deficit correlates with many features of PD such as bradykinesia, but not tremor; and why PD subjects with a tremor-predominant presentation tend to have a more benign prognosis. 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Mckeown</name><name sortKey="Stevenson, James" sort="Stevenson, James" uniqKey="Stevenson J" first="James" last="Stevenson">James Stevenson</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M" last="Lewis">Mechelle M. Lewis</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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